Antimicrobial resistance and antibiotic biosynthesis in soils: developing key understanding and counteractive strategies using a One-Health approach

Expected Outcome: Activities under this topic will help progress towards the objectives and targets of the Mission Soil and of the EU Soil Strategy for 2030 , the Zero Pollution Action Plan , the European One Health Action Plan against antimicrobial resistance as well as the Sustainable Development Goals [1] . Project results are expected to contribute to all the following expected outcomes: policymakers, land managers and other relevant stakeholders have an enhanced understanding of antimicrobial resistance development in soils, the key drivers and pathways of soil’s contribution to human and animal exposure to antimicrobial resistant genes and organisms, as well as antibiotic biosynthesis in soils; policymakers and land managers have increased access and capacity to implement evidence-based strategies aimed at reducing the risk of antimicrobial resistance development in soils and minimising the exposure of humans and animals to antimicrobial resistant genes and organisms; policymakers and other relevant stakeholders benefit from improved access to enriched databases of antibiotics-related genes and antibiotic alternatives from soil microorganisms; citizens are more aware of the importance of soil and soil biodiversity for human, animal and environmental health as well as on their potential as a source of molecules of interest for pharmaceutical purposes. Scope: Soil biodiversity plays a major role in human, animal and ecosystem health. Soil microorganisms (bacteria and fungi) have been crucial in the discovery of antibiotics used in human and veterinary medicine. However, soils can also be a hotspot for antimicrobial resistance development and can play a key role in the transfer of antimicrobial resistance genes between organisms and environmental compartments. Antibiotic use is expected to increase globally due to the rising demand for food-producing animals, which may further exacerbate the development of antimicrobial resistance in soils. According to the World Health Organization, antimicrobial resistance is one of the greatest threats to public health [2] . The driving forces for antimicrobial resistance development in soils are however understudied, as well as the role of soils in the exposure of humans and animals to antimicrobial resistance determinants. Moreover, our knowledge of antibiotics-related genes is currently limited, making it challenging to identify new compounds of interest. To better understand and combat antimicrobial resistance development in soils, a One-Health approach is needed. Proposals should: explore the source and dynamics of antimicrobial resistance development and the mechanisms for antibiotic biosynthesis in soils across all relevant land use types. The role of land use, land management practices and other environmental and anthropogenic driving factors should be identified and taken into account; analyse the role of soils in the transfer of antimicrobial resistance genes among organisms and environmental compartments and in the exposure of humans and animals to antimicrobial resistance genes and organisms; expand databases of antibiotics-related genes and antibiotic alternatives from soil microorganisms; develop concrete guidelines for policymakers and land managers to: i) better address the exposure of humans and animals to antimicrobial resistant genes and organisms; and, ii) facilitate the discovery of new molecules of pharmaceutical interest; carry out communication and awareness raising activities targeted to citizens on the importance of soil and soil biodiversity for human, animal and environmental health as well as on their potential as a source of molecules of interest for pharmaceutical purposes. In carrying out the activities, consortia should work in an interdisciplinary way bringing together life sciences, environmental sciences, health sciences and veterinary sciences. Proposals are expected to collaborate with the projects funded under HORIZON-HLTH-2024-DISEASE-09-01: European Partnership: One Health Anti-Microbial Resistance. Proposals should also demonstrate a route towards open access, longevity, sustainability and interoperability of knowledge and outputs through close collaboration with the EU Soil Observatory and the SoilWise project. Proposals should therefore include dedicated tasks and appropriate resources for collaboration with relevant projects and initiatives and engage in relevant Mission Soil clustering activities. [1] In particular SDG 3- Good health and well-being, and SDG 15 – Life on Land. [2] https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance

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